Malignant Hyperthermia
Cardiac and General Anesthesiology
APRIL 23, 2022
Malignant Hyperthermia Malignant hyperthermia (MH) is a rare (incidence of 1 in 50,000–70,000 in the UK), autosomal dominant condition, affecting males (62%) more than females (38%) and may occur after many previous anaesthetics. Mechanism The exact mechanism has not been fully elucidated but the ryanodine receptor located on the membrane of the sarcoplasmic reticulum and encoded on chromosome 19 is intimately involved.
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